Pelosi, speaking to reporters on Thursday, said she's confident she has the support in her caucus.
But it isn't only previous Democratic critics of Pelosi who are calling for a change.
Pelosi was tied closely to Ossoff during the campaign leading up to the local election, and some in the party blame her directly for the loss.
Let me pause here to say that just as winning this race for Republicans was a morale booster, losing this race definitely kicks Democrats in the gut.
Though Pelosi has done some good work, Ossoff's loss raises an interesting question - does the Democratic party need to rid itself of some of its most toxic symbols of establishment if we hope to regain anything in 2018 and beyond?
BENNETT: Like Ryan, Congressman Seth Moulton of MA is also venting about the loss.
"Those issues are very important, and I don't think we should yield any ground at all on those issues because they're vital to our society when you're talking about refugees, you're talking about a woman's right to choose, when you're talking about voting rights", he said. It's time for new leadership.
In the well-to-do Atlanta suburbs, House Minority Leader Nancy Pelosi of California was the focus of torrents of negative advertising in a House race that cost more than $50 million, the most expensive in history.
Progressives certainly aren't cozy with Pelosi, and have called for her to no longer serve as a Democratic party figurehead. You're responsible for everything your platoon does or fails to do.
"I think our leadership owes an explanation of what happened, how resources were spent, but also a plan going forward", Moulton said yesterday. That's the most important part.
On Tuesday, Republican Karen Handel won a fierce, closely-watched special congressional election in Georgia, staving off a spirited challenge from Democrat Jon Ossoff. She believes the time has come for Nancy Pelosi to step aside for the betterment of the party. But the obvious hypocrisy touting the need for campaign finance reform all while outspending his Republican opponent by almost seven to one seemed lost on Ossoff.
RYAN: Those are still effective ads that hurt our candidates.
"You want people to understand how you feel about your God, well I know how you feel about your God", she added.
BENNETT: Again, that's Congressman Tim Ryan.
Prior to Tuesday, analysts said the combination of the Russian investigations, public pushback, and a tight schedule could derail several of Trump's agenda items.
In this March 28, 2017 photo, House Ways and Means Committee member Rep. Bill Pascrell Jr., D-N.J. speaks during a meeting on Capitol Hill in Washington.